A scalable nanoimprinting process is used to fabricate a high-performance flexible piezoelectric nanogenerator made of piezoelectrically enhanced polyvinylidene fluoride-trifluoroethylene/barium titanate nanocomposite micropillar array, which can turn on various consumer electronics devices and can be demonstrated as self-powered flexible sensors for detecting air pressure/flow and some human vital signs such as breath and heartbeat pulse. This work is reported by Xiaoliang Chen, Xiangming Li, Jinyou Shao,* Ningli An,* Hongmiao Tian, Chao Wang, Tianyi Han, Li Wang, and Bingheng Lu in the article 10.1002/smll.201604245. To find out more, please visit the Small homepage.