Seongtae Bae教授和来自南卡罗来纳大学 (University of South Carolina),首尔大学医学院 (Seoul National University College of Medicine),横滨国立大学 (Yokohama National University)和奥古斯塔大学 (Augusta University)的合作者们在他们发表在Advanced Materials的文章中,开发出了一个具有高度生物相容性及超强顺磁性的纳米颗粒MNFH药物,这一药物展现出了潜在的完全杀死肿瘤的热疗效果。
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医学的进步带来了更为安全、有效的癌症治疗方法。相比于传统的化疗或放射治疗,磁流体热疗 (MNFH) 药物具有副作用小、疗效高的优势。然而,生物相容性仍然是其能否成功应用于临床的一个至关重要挑战。
Seongtae Bae教授和来自南卡罗来纳大学 (University of South Carolina),首尔大学医学院 (Seoul National University College of Medicine),横滨国立大学 (Yokohama National University)和奥古斯塔大学 (Augusta University)的合作者们在他们发表在Advanced Materials的文章中,开发出了一个具有高度生物相容性及超强顺磁性的纳米颗粒MNFH药物,这一药物展现出了潜在的完全杀死肿瘤的热疗效果。
镁浅掺杂氧化铁 (Mg0.13-γFe2O3) 超强顺磁性纳米颗粒 (SPNPs) 是采用热分解法合成的。乙酸镁和铁 (III) 乙酰丙酮金属前驱体在油酸和有机溶剂中进行混合,并且在鼓泡通入氧/氩混合气的条件下加热。通过改变金属前驱体的初始摩尔比,可以实现Mg2+的掺杂浓度和分布在0~0.15 at%之间有规律的变化。
约50%的Fe空位被Mg2+占据的SPNPs具有最高的直流 (DC) 饱和磁矩和交流 (AC) 磁化率。在较低的交流磁场中,SPNPs显示出异常高的最大交流加热温度,可以达到180 °C,而与之相比,MgFe2O4 SPNPs的则为22 °C。并且上述SPNPs的磁化率比MgFe2O4和Fe3O4更高。
涂覆有甲氧基聚乙二醇硅烷 (PEG) 的SPNPs可以形成纳米流体。将Hep3B (肝癌细胞) 细胞转染荧光素酶生长在小鼠皮下,取100 µL的SPNP纳米流体通过瘤内注射的方式注入肿瘤组织,然后把小鼠放置在一个交流电磁线圈环境中,并且将其暴露在交流磁场中900 s。注射有SPNP纳米流体的Hep3B细胞迅速升温并在50.2 °C趋于饱和。两天后,Hep3B介导的纳米流体癌症治疗的结果显示并无生物发光活性,表明使用SPNP纳米流体的磁流体热疗法使肿瘤完全坏死。
想要了解更多关于这种基于超强顺磁性纳米粒子的热疗药物,请访问Advanced Materials的主页。